Endocrine Abstracts

Introduction: VPA, antiepileptic drug, may cause a number of side effects including reproductive deficits in humans. Previously we found that VPA (1 μM) may suppress GnRH-stimulated release of LH from rat anterior pituitary cells in vitro without affecting its basal secretion (Neuroendocrinol Lett 2011 32 101–106). However mechanism of VPA suppressive activity is still unknown. Since pharmacological effects of VPA require GnRH-R activation, the m...

Background: Thyroid dysfunction and lipid profile are associated with cardiovascular disease in patients with autoimmune thyroiditis (AIT).Objective: To evaluate the association between thyroid function, lipid concentrations, C-reactive protein (CRP) and homocysteine in patients with AIT.Patients and methods: We assessed thyroid function tests, BMI, total cholesterol (TC), HDL-cholesterol, LDL-cholesterol, triglycerides (TG), apoli...

Introduction: Elevated high-sensitive c-reactive protein (hs-CRP) in association with hyperinsulinemia, obesity, insulin resistance and high blood pressure are significant risk factors for cardiovascular diseases. The aim of this study is to evaluated the correlations between serum hs-CRP concentration and metabolic risk factors in overweight and obese women.Methods: Overweight (BMI>25 kg/m2) and obese (BMI>30 kg/m2) 755 wom...

BackgroundDyslipidemia is relevant association of hypothyroidism and consists of raised levels of total cholesterol, apolipoprotein B, triglycerides, low density lipoprotein (LDL) cholesterol, and reduced levels of high density lipoprotein (HDL) cholesterol.Thyroid hormones also have a role in modulating glucose metabolism and insulin resistance. The aim of study was to assess glycemic status, Homeostasis model assessment–estimated Insulin Resistanc...

Introduction: Neonate of patients with type I diabetes (T1D) are at increased risk for neonatal hypoglycemia. It is hypothesized that this is a result of maternal hyperglycemia and subsequent fetal hyperinsulinemia.Aim: The aim of this study was to determine the relationship between clinically significant neonatal hypoglycemia (CS-hypo) and cord-blood c-peptide (CBCP) concentrations in patients with T1D.Materials and methods: This ...

Introduction: β-cell function declines progressively in patients with type 2 diabetes (T2D). the fasting C-peptide/glucose ratio (Cp/G) is used for its evaluation. The GLP1 receptor agonist liraglutide improves glucose and weight control, presumably due to improvement of β-cell function and/or mass. This study evaluates the effect of a 6-months’ treatment with liraglutide in β-cell function, measured by Cp/G, in patients with obesity and T2D.<p class="a...

Background: Residual C-peptide (CP) secretion has been associated with better glycemic control in patients with type 1 diabetes (T1D).Aim: To evaluate how residual fasting CP (fCP) secretion impacts glycemic control in T1D and to identify possible confounding factors.Methods: A retrospective analysis of adult patients with T1D followed in our department that had their fCP and glucose levels obtained on the same blood sample during ...

Introduction: Long term control of glucotoxicity has been shown to increase the secretion of insulin and C-peptide (Cp) from beta cells. However, there is limited data concerning the effect of short term glycemic control and reversal of glucotoxicity on basal Cp. We aimed to investigate the change in serum Cp levels after short term glycemic control in patients with uncontrolled type 2 diabetes mellitus (DM).Materials and methods: A total of 123 patients...

Background and aims: DM2 has been associated with altered levels of trace elements and a prothrombotic state. We investigated the effect of a 28-day Greek mediterranean diet (rich in fiber, mono- and polyunsaturated fatty acids and complex carbohydrates) on serum concentration of trace ele-ments and blood factors participating in coagulation and fibrinolysis in 58 patients with DM2.Materials and methods: Blood trace elements and blood coagulation fac-tor...

A 75 year old woman was treated for over three years with the somatostatin analogue, octreotide for insulinoma. She had presented in a hypoglycaemic coma. C-peptide and insulin levels were both raised. Cortisol, TSH, a gut hormone screen and urinary sulphonylurea levels were all normal. No adenoma was identified on CT or MRI scanning but angiography showed an area of increased vascularity within the pancreas. At laparotomy no lesion was found and no resection was undertaken. B...